Gabapentin Concentrations and Postmortem Distribution

Highlights • 30 postmortem cases were investigated. • The central to peripheral blood ratio median was 0.97 • The liver to peripheral blood (L/P) ratio median was 0.65 L/kg • The same levels were found in an antemortem blood and postmortem peripheral blood • The data suggests that gabapentin is unli...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international 2016-05, Vol.262, p.201-203
Main Authors: Hamm, Catherine E, Gary, Ray D, McIntyre, Iain M
Format: Article
Language:English
Subjects:
Alcohol
Amines - analysis
Amines - pharmacokinetics
Anticonvulsants - analysis
Anticonvulsants - pharmacokinetics
Blood
Cardiovascular disease
Chromatography
Cyclohexanecarboxylic Acids - analysis
Cyclohexanecarboxylic Acids - pharmacokinetics
Deviation
Dosing
Drug distribution
Edema
Epilepsy
Fatigue (materials)
Forensic science
Forensic sciences
Gabapentin
gamma-Aminobutyric Acid - analysis
gamma-Aminobutyric Acid - pharmacokinetics
Gas Chromatography-Mass Spectrometry
Humans
Injuries
Library collections
Liver
Liver - chemistry
Male
Middle Aged
Pathology
Poisons
Postmortem
Postmortem Changes
Redistribution
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 30 postmortem cases were investigated. • The central to peripheral blood ratio median was 0.97 • The liver to peripheral blood (L/P) ratio median was 0.65 L/kg • The same levels were found in an antemortem blood and postmortem peripheral blood • The data suggests that gabapentin is unlikely to show postmortem redistribution
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2016.03.028