The euglobulin clot lysis time to assess the impact of nanoparticles on fibrinolysis

Nanoparticles (NPs) are developed for many applications in various fields, including nanomedicine. The NPs used in nanomedicine may disturb homeostasis in blood. Secondary hemostasis (blood coagulation) and fibrinolysis are complex physiological processes regulated by activators and inhibitors. An i...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2015-07, Vol.17 (7), p.1-9, Article 317
Main Authors: Minet, Valentine, Alpan, Lutfiye, Mullier, François, Toussaint, Olivier, Lucas, Stéphane, Dogné, Jean-Michel, Laloy, Julie
Format: Article
Language:English
Subjects:
Black carbon
BLOOD
Blood coagulation
Characterization and Evaluation of Materials
CHEMICAL PROPERTIES
Chemistry and Materials Science
COAGULATION
Fibrin
Homeostasis
IMPACT PROPERTIES
Inorganic Chemistry
Lasers
Materials Science
MEDICINE
MICROSTRUCTURES
Nanoparticles
Nanostructure
Nanotechnology
Optical Devices
Optics
PARTICLES
Photonics
Physical Chemistry
Physicochemical properties
Research Paper
Screening
Silicon
Silicon carbide
Silver
Thromboembolism
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Summary:Nanoparticles (NPs) are developed for many applications in various fields, including nanomedicine. The NPs used in nanomedicine may disturb homeostasis in blood. Secondary hemostasis (blood coagulation) and fibrinolysis are complex physiological processes regulated by activators and inhibitors. An imbalance of this system can either lead to the development of hemorrhages or thrombosis. No data are currently available on the impact of NPs on fibrinolysis. The objectives of this study are (1) to select a screening test to study ex vivo the impact of NPs on fibrinolysis and (2) to test NPs with different physicochemical properties. Euglobulin clot lysis time test was selected to screen the impact of some NPs on fibrinolysis using normal pooled plasma. A dose-dependent decrease in the lysis time was observed with silicon dioxide and silver NPs without disturbing the fibrin network. Carbon black, silicon carbide, and copper oxide did not affect the lysis time at the tested concentrations.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-015-3110-6