Seasonal changes in the tetrodotoxin content of the pufferfish Takifugu niphobles

To investigate seasonal changes in the whole body content and tissue distribution of tetrodotoxin (TTX) in the pufferfish Takifugu niphobles, wild individuals were collected from the coastal waters around Miura Peninsula from November 2010 to May 2012, and their tissues were subjected to LC-MS/MS an...

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Bibliographic Details
Published in:Toxicon (Oxford) 2016-05, Vol.114, p.53-58
Main Authors: Itoi, Shiro, Ishizuka, Kento, Mitsuoka, Ryoko, Takimoto, Narumi, Yokoyama, Naoto, Detake, Ayumi, Takayanagi, Chie, Yoshikawa, Saori, Sugita, Haruo
Format: Article
Language:English
Subjects:
Animals
Chromatography, Liquid
Coastal water
Female
Females
Fish
Liver - metabolism
Male
Males
Marine
Maturation
Ovary - metabolism
Pufferfish
Seasons
Sexual Behavior, Animal
Sexual Maturation
Skin - metabolism
Takifugu - metabolism
Takifugu niphobles
Tandem Mass Spectrometry
Tetrodotoxin
Tetrodotoxin - isolation & purification
Tetrodotoxin - metabolism
TTX
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Summary:To investigate seasonal changes in the whole body content and tissue distribution of tetrodotoxin (TTX) in the pufferfish Takifugu niphobles, wild individuals were collected from the coastal waters around Miura Peninsula from November 2010 to May 2012, and their tissues were subjected to LC-MS/MS analysis. Fish that were sexually mature were classified as being in the maturation period (April), the spawning period (May–July) or the “ordinary period” (i.e., other months). In both sexes, gonad somatic index rapidly increased during the maturation period and then decreased during the spawning period. Whole body TTX content was significantly higher during the maturation/spawning period than in the ordinary period. Through all seasons, TTX was localized in the skin or ovary in females and in the skin or liver in males: the difference in TTX localization between females and males was particularly evident during the spawning period. •The female pufferfishes Takifugu niphobles accumulated TTX in the skin or ovaries.•The male pufferfishes accumulated TTX in the skin or liver.•The whole body TTX content was higher in the maturation/spawning than outside that.•The localization of TTX differed markedly between sexes during the spawning period.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2016.02.020