Evaluation of a custom single Peltier-cooled ablation cell for elemental imaging of biological samples in laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)

The advent of laser ablation coupled to inductively coupled plasma-mass spectrometry has allowed for the elemental analysis of solid samples in their native state, or with little sample preparation required. Furthermore, with the addition of a cooled ablation cell spatially resolved elemental imagin...

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Bibliographic Details
Published in:Journal of analytical atomic spectrometry 2016-01, Vol.31 (4), p.13-133
Main Authors: Hamilton, J. S, Gorishek, E. L, Mach, P. M, Sturtevant, D, Ladage, M. L, Suzuki, N, Padilla, P. A, Mittler, R, Chapman, K. D, Verbeck, G. F
Format: Article
Language:English
Subjects:
Ablation
Biological
Imaging
Joining
Laser ablation
Sampling
Spectrometry
Spectroscopy
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Summary:The advent of laser ablation coupled to inductively coupled plasma-mass spectrometry has allowed for the elemental analysis of solid samples in their native state, or with little sample preparation required. Furthermore, with the addition of a cooled ablation cell spatially resolved elemental imaging of soft and semi-soft samples, specifically biological tissues, is attainable. A new single Peltier element laser ablation cell is described and a demonstration of its applicability to biological sampling is discussed to evaluate its performance. Through the analysis of three different biological tissues the device is shown to provide spatially resolved images of mapped elements while maintaining the structural integrity of the tissues during the hours long sampling times. A new single Peltier element ablation cell is described and its applicability to biological sampling discussed to evaluate its performance.
ISSN:0267-9477
1364-5544
DOI:10.1039/c5ja00433k