Computational modeling of cardiac hemodynamics: Current status and future outlook

The proliferation of four-dimensional imaging technologies, increasing computational speeds, improved simulation algorithms, and the widespread availability of powerful computing platforms is enabling simulations of cardiac hemodynamics with unprecedented speed and fidelity. Since cardiovascular dis...

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Bibliographic Details
Published in:Journal of computational physics 2016-01, Vol.305, p.1065-1082
Main Authors: Mittal, Rajat, Seo, Jung Hee, Vedula, Vijay, Choi, Young J., Liu, Hang, Huang, H. Howie, Jain, Saurabh, Younes, Laurent, Abraham, Theodore, George, Richard T.
Format: Article
Language:English
Subjects:
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Blood flow
Cardiac auscultation
Cardiac physics
Cardiac surgery
Cardiovascular disease
Computation
Computational fluid dynamics
Computer simulation
Diagnosis
Heart disease
Heart murmurs
Hemodynamics
Image segmentation
Immersed boundary methods
Left ventricular thrombosis
Mathematical models
Medical services
Modelling
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Summary:The proliferation of four-dimensional imaging technologies, increasing computational speeds, improved simulation algorithms, and the widespread availability of powerful computing platforms is enabling simulations of cardiac hemodynamics with unprecedented speed and fidelity. Since cardiovascular disease is intimately linked to cardiovascular hemodynamics, accurate assessment of the patient's hemodynamic state is critical for the diagnosis and treatment of heart disease. Unfortunately, while a variety of invasive and non-invasive approaches for measuring cardiac hemodynamics are in widespread use, they still only provide an incomplete picture of the hemodynamic state of a patient. In this context, computational modeling of cardiac hemodynamics presents as a powerful non-invasive modality that can fill this information gap, and significantly impact the diagnosis as well as the treatment of cardiac disease. This article reviews the current status of this field as well as the emerging trends and challenges in cardiovascular health, computing, modeling and simulation and that are expected to play a key role in its future development. Some recent advances in modeling and simulations of cardiac flow are described by using examples from our own work as well as the research of other groups.
ISSN:0021-9991
1090-2716
DOI:10.1016/j.jcp.2015.11.022