Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents

The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd(3+) diethylenetriaminepentaacetate and Gd(3+) diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2015-01, Vol.44 (47), p.20728-20734
Main Authors: Jin, Miao, Spillane, Dominic E M, Geraldes, Carlos F G C, Williams, Gareth R, Bligh, S W Annie
Format: Article
Language:English
Subjects:
Contrast agents
Contrast Media - chemistry
Coordination Complexes - chemistry
Diffraction
Gadolinium - chemistry
Gadolinium DTPA - chemistry
Infrared spectroscopy
Intercalation
Intercalation compounds
Magnetic Resonance Imaging
Microwaves
Organophosphorus Compounds - chemistry
Salts
Vibration
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Summary:The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd(3+) diethylenetriaminepentaacetate and Gd(3+) diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5-18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd(3+) complexes in the intercalation compounds. The proton relaxivities of the Gd(3+) complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.
ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt03433g