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Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy enhances real-time in vivo diagnosis of adenomatous polyps during colonoscopy

Colorectal cancer can be prevented if detected early (e.g., precancerous polyps‐adenoma). Endoscopic differential diagnosis of hyperplastic polyps (that have little or no risk of malignant transformation) and adenomas (that have prominent malignant latency) remains an unambiguous clinical challenge....

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Bibliographic Details
Published in:Journal of biophotonics 2016-04, Vol.9 (4), p.333-342
Main Authors: Bergholt, Mads Sylvest, Lin, Kan, Wang, Jianfeng, Zheng, Wei, Xu, Hongzhi, Huang, Qingwen, Ren, Jian-lin, Ho, Khek Yu, Teh, Ming, Srivastava, Supriya, Wong, Benjamin, Yeoh, Khay Guan, Huang, Zhiwei
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Language:English
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Summary:Colorectal cancer can be prevented if detected early (e.g., precancerous polyps‐adenoma). Endoscopic differential diagnosis of hyperplastic polyps (that have little or no risk of malignant transformation) and adenomas (that have prominent malignant latency) remains an unambiguous clinical challenge. Raman spectroscopy is an optical vibrational technique capable of probing biomolecular changes of tissue associated with neoplastic transformation. This work aims to apply a fiber‐optic simultaneous fingerprint (FP) and high wavenumber (HW) Raman spectroscopy technique for real‐time in vivo assessment of adenomatous polyps during clinical colonoscopy. We have developed a fiber‐optic Raman endoscopic technique capable of simultaneously acquiring both the FP (i.e., 800–1800 cm–1) and HW (i.e., 2800–3600 cm–1) Raman spectra from colorectal tissue subsurface (
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201400141