Sources of Antimicrobial Resistance

The relentless rise in levels of antimicrobial resistance is an unfolding global public health crisis (1). Resistance to frontline antimicrobials such as fluoroquinolones, third- and fourth-generation cephalosporins, and carbapenems is a particular concern, as is multidrug resistance. The antimicrob...

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Published in:Science (American Association for the Advancement of Science) 2013-09, Vol.341 (6153), p.1460-1461
Main Authors: Woolhouse, Mark E. J., Ward, Melissa J.
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobials
Bacteria
Cattle
Cephalosporin
Drug resistance
Farms
Genetics
Human
Human populations
Humans
Livestock
Mathematical problems
Medicine
PERSPECTIVES
Public health
Salmonella
Salmonella typhimurium
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description The relentless rise in levels of antimicrobial resistance is an unfolding global public health crisis (1). Resistance to frontline antimicrobials such as fluoroquinolones, third- and fourth-generation cephalosporins, and carbapenems is a particular concern, as is multidrug resistance. The antimicrobial resistance problem is not confined to human medicine: Comparable quantities of antimicrobials are used in livestock production, and resistance is rife in that setting, too, even on organic farms that restrict drug usage (2). Such observations have led to debate about whether antimicrobial resistance in farm animals is an important source of antimicrobial resistance in humans (3, 4). On page 1514 of this issue, Mather et al. (5) shed light on this important question in the context of Salmonella Typhimurium DT104 in humans and cattle in Scotland.
doi_str_mv 10.1126/science.1243444
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source American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection; Alma/SFX Local Collection
subjects Antibiotic resistance
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobials
Bacteria
Cattle
Cephalosporin
Drug resistance
Farms
Genetics
Human
Human populations
Humans
Livestock
Mathematical problems
Medicine
PERSPECTIVES
Public health
Salmonella
Salmonella typhimurium
title Sources of Antimicrobial Resistance
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