Fine Tuning Gene Regulation

On page 816 of this issue, Kim et al. (1) report that a DNA-bound protein can influence the properties of an adjacent protein if both are bound to the DNA strand within about 15 base pairs (bp) of each other. The authors attribute their observations to an allosteric effect, in which a distortion of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2013-02, Vol.339 (6121), p.766-767
Main Author: Crothers, Donald M.
Format: Article
Language:English
Subjects:
Binding
Deoxyribonucleic acid
Distortion
DNA
Gene expression
Kinetics
PERSPECTIVES
Proteins
Strands
Tuning
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Summary:On page 816 of this issue, Kim et al. (1) report that a DNA-bound protein can influence the properties of an adjacent protein if both are bound to the DNA strand within about 15 base pairs (bp) of each other. The authors attribute their observations to an allosteric effect, in which a distortion of the DNA strand by the first protein modulates the binding of the second protein. The observations have important implications for gene regulation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1232663