Formation of molecular hydrogels from a bile acid derivative and selected carboxylic acids

Bile acids are natural compounds that can be made into dimers by covalently linking two of them through diethylenetriamine. A cholic acid dimer of this kind is synthesized and is found to form thermally reversible hydrogels with selected carboxylic acids through combined hydrogen bonding and ionic i...

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Published in:RSC advances 2016-01, Vol.6 (42), p.35436-3544
Main Authors: Zhang, Meng, Waldron, Karen C, Zhu, X. X
Format: Article
Language:English
Subjects:
Carboxylic acids
Covalence
Derivatives
Dimers
Formations
Hydrogels
Hydrogen bonding
Ionic interactions
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description Bile acids are natural compounds that can be made into dimers by covalently linking two of them through diethylenetriamine. A cholic acid dimer of this kind is synthesized and is found to form thermally reversible hydrogels with selected carboxylic acids through combined hydrogen bonding and ionic interactions. The gelation and viscoelastic properties of the hydrogels may be varied by judicious choice of the carboxylic mono- and diacids. The total organic content (the dimer and carboxylic acid) represents about 2% or less by weight in the ternary mixture. The molecular arrangement between the dimer and carboxylic acid is proposed to illustrate the formation mechanism of the hydrogels. The marginal solubility of the dimeracid mixtures seems to be the deciding factor in obtaining the hydrogels. A cholic acid dimer forms hydrogels with selected carboxylic acids via protonation and hydrogen bonding.
doi_str_mv 10.1039/c6ra04536g
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Carboxylic acids
Covalence
Derivatives
Dimers
Formations
Hydrogels
Hydrogen bonding
Ionic interactions
title Formation of molecular hydrogels from a bile acid derivative and selected carboxylic acids
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