Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications

Mg-1Ca/HA composites were produced by blending magnesium-calcium (1wt%) (Mg-1Ca) alloys with 5, 10 and 15wt% of hydroxyapatite (HA). Morphology, elemental and phase composition of Mg-1Ca/HA composites were examined. Biocompatibility assessments were also performed using an indirect contact method by...

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Bibliographic Details
Published in:Materials letters 2016-06, Vol.172, p.193-197
Main Authors: Lim, P.N., Lam, R.N., Zheng, Y.F., Thian, E.S.
Format: Article
Language:English
Subjects:
Alloys
Biocompatibility
Biomedical materials
Composites
Hydroxyapatite
Magnesium
Magnesium base alloys
Magnesium-calcium
Orthopedics
Stem cells
Surgical implants
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Summary:Mg-1Ca/HA composites were produced by blending magnesium-calcium (1wt%) (Mg-1Ca) alloys with 5, 10 and 15wt% of hydroxyapatite (HA). Morphology, elemental and phase composition of Mg-1Ca/HA composites were examined. Biocompatibility assessments were also performed using an indirect contact method by culturing human adipose mesenchymal stem cells (hASCs) in the extracts of Mg-1Ca alloy, Mg-1Ca/HA composites and Dulbecco's modified eagle's medium. Mg-1Ca/HA composites could promote cell proliferation and at the same time, enhanced collagen type I (COL I) and osteocalcin (OCN) expressions of hASCs. Among the Mg-1Ca/HA composites, 10wt% of HA is the optimum amount to be added into Mg-1Ca alloy for enhanced bioactivity, thus emerging as a potential biomaterial for orthopedic fixation. •Mg-1Ca/HA composites containing 5, 10 and 15wt% of HA were formed.•Apatite and α-Mg phases were detected in the Mg-1Ca/HA composites.•Mg-1Ca/10HA composite showed better enhancement in bone differentiation markers.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2016.03.005