Immobilization of two organometallic complexes into a single cage to construct protein-based microcompartments

Natural protein-based microcompartments containing multiple enzymes promote cascade reactions within cells. We use the apo-ferritin protein cage to mimic such biocompartments by immobilizing two organometallic Ir and Pd complexes into the single protein cage. Precise locations of the metals and thei...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (31), p.5463-5466
Main Authors: Maity, Basudev, Fukumori, Kazuki, Abe, Satoshi, Ueno, Takafumi
Format: Article
Language:English
Subjects:
Animals
Apoferritins - chemistry
Cage
Crystallography
Crystallography, X-Ray
Enzymes
Horses
Immobilization
Iridium
Iridium - chemistry
Metalorganic compounds
Models, Molecular
Organometallic Compounds - chemistry
Palladium - chemistry
Proteins
X-rays
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Summary:Natural protein-based microcompartments containing multiple enzymes promote cascade reactions within cells. We use the apo-ferritin protein cage to mimic such biocompartments by immobilizing two organometallic Ir and Pd complexes into the single protein cage. Precise locations of the metals and their accumulation mechanism were studied by X-ray crystallography.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc00679e