Facile Synthesis of Bisphosphonates

Sodium hydride in polyethylene glycol has been used as a sustainable, non-volatile, and ecofriendly catalytic medium for the green synthesis of bisphosphonates with an alkyl/aryl/heterocyclic group fixed at the geminai carbon. All compounds (3a-j) were characterized by IR, super(1)H and super(31)P N...

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Bibliographic Details
Published in:INTERNATIONAL JOURNAL OF THE SOCIETY OF MATERIALS ENGINEERING FOR RESOURCES 2014-04, Vol.20 (1), p.45-48
Main Authors: KUNDA, Uma Maheswara Rao, HAMADA, Fumio
Format: Article
Language:English
Subjects:
Aromatic compounds
Carbon
Economics
Infrared radiation
Materials engineering
Polyethylene glycol
Recyclability
Sustainability
Synthesis
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Summary:Sodium hydride in polyethylene glycol has been used as a sustainable, non-volatile, and ecofriendly catalytic medium for the green synthesis of bisphosphonates with an alkyl/aryl/heterocyclic group fixed at the geminai carbon. All compounds (3a-j) were characterized by IR, super(1)H and super(31)P NMR, mass and elemental analysis. The easy recyclability of the reaction medium makes the reaction economically and potentially viable for commercial applications.
ISSN:1347-9725
1884-6629
DOI:10.5188/ijsmer.20.45