Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes

In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens....

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Bibliographic Details
Published in:Nano letters 2016-02, Vol.16 (2), p.1502-1508
Main Authors: Limaj, Odeta, Etezadi, Dordaneh, Wittenberg, Nathan J, Rodrigo, Daniel, Yoo, Daehan, Oh, Sang-Hyun, Altug, Hatice
Format: Article
Language:English
Subjects:
Biomimetics
Biosensing Techniques
Biosensors
Kinetics
Lipids
Membrane Lipids - chemistry
Membrane Lipids - isolation & purification
Membranes
Monitoring
Nanostructure
Nanostructures - chemistry
Plasmonics
Real time
Spectrophotometry, Infrared
Surface Plasmon Resonance
Water - chemistry
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Summary:In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens. By exploiting the plasmonic field enhancement in the vicinity of engineered and surface-modified nanoantennas, the proposed biosensor is able to capture the vibrational fingerprints of lipid molecules and monitor in real time the formation kinetics of planar biomimetic membranes in aqueous environments. Furthermore, we show that this plasmonic biosensor features high-field enhancement extending over tens of nanometers away from the surface, matching the size of typical bioassays while preserving high sensitivity.
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.5b05316