Particle-based simulations of red blood cells—A review

Abstract Particle-based methods have been increasingly attractive for solving biofluid flow problems, because of the ease and flexibility in modeling complex structure fluids afforded by the methods. In this review, we focus on popular particle-based methods widely used in red blood cell (RBC) simul...

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Bibliographic Details
Published in:Journal of biomechanics 2016-07, Vol.49 (11), p.2255-2266
Main Authors: Ye, Ting, Phan-Thien, Nhan, Lim, Chwee Teck
Format: Article
Language:English
Subjects:
Atoms & subatomic particles
Behavior
Computer Simulation
Cytoplasm
Dissipative particle dynamics
Erythrocytes - physiology
Fluids
Hydrodynamics
Lattice Boltzmann method
Methods
Models, Biological
Numerical analysis
Physical Medicine and Rehabilitation
RBC dynamics
RBC rheology
Rheology
Simulation
Smoothed particle hydrodynamics
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Summary:Abstract Particle-based methods have been increasingly attractive for solving biofluid flow problems, because of the ease and flexibility in modeling complex structure fluids afforded by the methods. In this review, we focus on popular particle-based methods widely used in red blood cell (RBC) simulations, including dissipative particle dynamics (DPD), smoothed particle hydrodynamics (SPH), and lattice Boltzmann method (LBM). We introduce their basic ideas and formulations, and present their applications in RBC simulations which are divided into three classes according to the number of RBCs in the simulation: a single RBC, two or multiple RBCs, and RBC suspension. Furthermore, we analyze their advantages and disadvantages. On weighing the pros and cons of the methods, a combination of the immersed boundary (IB) method and some forms of smoothed dissipative particle hydrodynamics (SDPD) methods may be required to deal effectively with RBC simulations.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2015.11.050