Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells

The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has flu...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2016-05, Vol.308 (2), p.659-670
Main Authors: Akman, Levent, Biber Muftuler, Fazilet Zumrut, Bilgi, Ahmet, Yurt Kilcar, Ayfer, Gokulu, Sevki Goksun, Medine, Emin Ilker, Terek, Mustafa Cosan
Format: Article
Language:English
Subjects:
Breast cancer
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Drug delivery systems
Fluorescence
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Ovarian cancer
Physical Chemistry
Tracers (Biology)
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Summary:The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer ( 131 I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-015-4472-z