Gemcitabine enhances Kras-MEK-induced matrix metalloproteinase-10 expression in gemcitabine-resistant pancreatic tumor-initiating cells

Methods: KMC07 cells were treated with gemcitabine, and gene expression and functional studies were investigated using microarray, quantitative polymerase chain reaction, immunoblot, immunohistochemistry, chromatin immunoprecipitation, and cell transplantation into nude mice.

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016-08, Vol.16 (4), p.S62-S62
Main Authors: Tsuchida, Yuka, Shimizu, Kazuya, Uenoyama, Kyouhei, Ise, Yuuki, Nishiyama, Satoshi, Hori, Yuichi
Format: Article
Language:English
Subjects:
Chemotherapy
Chromatin
Endocrinology & Metabolism
Gastroenterology and Hepatology
Gene expression
Online Access:Get full text
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Description
Summary:Methods: KMC07 cells were treated with gemcitabine, and gene expression and functional studies were investigated using microarray, quantitative polymerase chain reaction, immunoblot, immunohistochemistry, chromatin immunoprecipitation, and cell transplantation into nude mice.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2016.06.227