Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients

• Published in: Journal of human hypertension 2016-07, Vol.30 (7), p.414-417
• Main Authors: Papavasileiou, M V, Karamanou, A G, Kalogeropoulos, P, Moustakas, G, Patsianis, S, Pittaras, A
• Format: Article
• Language: English
• Subjects: 692/499; Adult; Aged; Analysis; Apolipoprotein A-I - blood; Apolipoprotein B-100 - blood; Apolipoproteins; Biomarkers - blood; Blood Glucose - metabolism; Blood levels; Blood Pressure; Cholesterol, HDL - blood; Diagnosis; Epidemiology; Female; Health Administration; High density lipoprotein; Humans; Hypertension; Hypertension - complications; Hypertension - diagnosis; Hypertension - physiopathology; Hyperuricemia - blood; Hyperuricemia - complications; Hyperuricemia - diagnosis; Lipids - blood; Male; Medicine; Medicine & Public Health; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Metabolic Syndrome - diagnosis; Metabolic Syndrome - physiopathology; Metabolic syndrome X; Middle Aged; original-article; Physiological aspects; Population studies; Public Health; Risk Factors; Statistical analysis; Triglycerides; Triglycerides - blood; Up-Regulation; Uric acid; Uric Acid - blood; Waist Circumference
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/jhh.2015.53

Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported. The aim of the study was to investigate the relationship between the components of MetS with the SUA levels as also between SUA and apolipoproteins A1 and B (apoA1 and apoB) ratio in hypertensive patients. A total of 2577 consecutive hypertensive patients (1193 male and 1384 female) aged 57.5±13.3 years, were enrolled in our research. Samples were taken to measure SUA, glucose, triglycerides, high density lipoprotein (HDL-C), components of the MetS and apoA1 and apoB. The study population was divided into two groups: group A: SUA levels above normal range (men ⩾7 mg dl −1 , women ⩾6 mg dl −1 ) and group B: SUA levels within normal range. In the overall study population, SUA levels showed a statistically significant correlation with waist circumference (WC; r =0.293, P