Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease

Patients with chronic obstructive pulmonary disease (COPD) have an increased risk for cardiovascular disease (CVD). Currently, COPD patients with atherosclerosis (i.e., the most important underlying cause of CVD) receive COPD therapy complemented with standard CVD therapy. This may, however, not be...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2016-06, Vol.310 (11), p.L1011-L1027
Main Authors: Khedoe, P Padmini S J, Rensen, Patrick C N, Berbée, Jimmy F P, Hiemstra, Pieter S
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Chronic obstructive pulmonary disease
Comorbidity
Disease Models, Animal
Humans
Hyperlipidemias - complications
Hyperlipidemias - epidemiology
Mice
Oxidative Stress
Pathogenesis
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - epidemiology
Risk Factors
Smoking - adverse effects
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Summary:Patients with chronic obstructive pulmonary disease (COPD) have an increased risk for cardiovascular disease (CVD). Currently, COPD patients with atherosclerosis (i.e., the most important underlying cause of CVD) receive COPD therapy complemented with standard CVD therapy. This may, however, not be the most optimal treatment. To investigate the link between COPD and atherosclerosis and to develop specific therapeutic strategies for COPD patients with atherosclerosis, a substantial number of preclinical studies using murine models have been performed. In this review, we summarize the currently used murine models of COPD and atherosclerosis, both individually and combined, and discuss the relevance of these models for studying the pathogenesis and development of new treatments for COPD patients with atherosclerosis. Murine and clinical studies have provided complementary information showing a prominent role for systemic inflammation and oxidative stress in the link between COPD and atherosclerosis. These and other studies showed that murine models for COPD and atherosclerosis are useful tools and can provide important insights relevant to understanding the link between COPD and CVD. More importantly, murine studies provide good platforms for studying the potential of promising (new) therapeutic strategies for COPD patients with CVD.
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00013.2016