Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer

We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer pr...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2016-07, Vol.124 (7), p.567-573
Main Authors: Qiu, Haifeng, Liu, Qiuli, Li, Juan, Wang, Xiujuan, Wang, Yuan, Yuan, Zhongfu, Li, Jing, Pei, Dong-Sheng
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
cancer susceptibility
Cervical cancer
China - epidemiology
Drug Resistance
Female
Genetic Predisposition to Disease
Genotyping Techniques
Hox transcript antisense intergenic RNA
Human papillomavirus
Humans
long non-coding RNA
Middle Aged
Papillomaviridae - classification
Papillomaviridae - isolation & purification
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Prognosis
Risk Assessment
RNA, Long Noncoding - genetics
rs920778 polymorphism
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
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Summary:We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population. Using the specific TaqMan PCR assay, we genotyped rs920778 in 215 cervical cancer patients and 430 age‐matched healthy controls. As shown in our data, TT genotype of rs920778 was significantly correlated with the upregulation of HOTAIR (p = 0.008). Compared with the healthy control, TT genotype and T allele notably indicated a much higher risk of cervical cancer [TT genotype: odds ratio (OR) = 2.186, 95% confidence interval (CI) = 1.378–3.466, p = 0.003; T allele: OR = 1.556, 95% CI = 1.221–1.981]. In addition, we also found that the TT genotype of rs920778 was correlated with advanced tumor stage (p = 0.039), highly histological grade (p = 0.013), lympho node metastasis (p 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12550