Guillain-Barré syndrome in the elderly

The aim of the study was to analyze specific features of Guillain‐Barré syndrome (GBS) in old people. The study included 403 GBS patients (62% young [80 years]). Diagnosis of GBS was made according to the National Institute of Neurological Disorders and Stroke (NINDS criteria). Severe disability (GB...

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Bibliographic Details
Published in:Journal of the peripheral nervous system 2016-06, Vol.21 (2), p.105-110
Main Authors: Peric, Stojan, Berisavac, Ivana, Stojiljkovic Tamas, Olivera, Rajic, Sonja, Babic, Milica, Cvijanovic, Milan, Dominovic-Kovacevic, Aleksandra, Basta, Ivana, Beslac-Bumbasirevic, Ljiljana, Lavrnic, Dragana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aging
diagnosis
disability
Disability Evaluation
elderly
Female
Guillain-Barre Syndrome - diagnosis
Guillain-Barre Syndrome - epidemiology
Guillain-Barre Syndrome - therapy
Guillain-Barré syndrome
Humans
Immunoglobulins, Intravenous - therapeutic use
Longitudinal Studies
Male
Middle Aged
Plasma Exchange - methods
Serbia - epidemiology
Severity of Illness Index
therapy
Young Adult
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Summary:The aim of the study was to analyze specific features of Guillain‐Barré syndrome (GBS) in old people. The study included 403 GBS patients (62% young [80 years]). Diagnosis of GBS was made according to the National Institute of Neurological Disorders and Stroke (NINDS criteria). Severe disability (GBS disability score of >3) at nadir was more common in old compared with young patients (p = 0.0001) as was mortality (9% vs. 2%, respectively). Acute motor and sensory axonal neuropathy and hyponatremia were more common in old compared with young patients (12% vs. 6% and 27% vs. 18%, respectively, p = 0.04). A positive history for malignancy was more than three times more common in old than young patients (11% vs. 3%, respectively, p = 0.01). Disability on nadir was similar in young‐old and old‐old subjects with disability on discharge being more severe in old‐old (p = 0.04) suggesting slower recovery in this subgroup. Bulbar symptoms were more common in old‐old compared with young‐old (50% vs. 19%, respectively, p = 0.01). Comorbidities were present in virtually all old‐old patients compared with 66% of young‐old patients (p = 0.04). In conclusion, Elderly patients, and especially old‐old patients, with GBS have more severe disease with slower recovery than do younger patients.
ISSN:1085-9489
1529-8027
DOI:10.1111/jns.12163