Fampridine-PR (prolonged released 4-aminopyridine) is not effective in patients with inflammatory demyelination of the peripheral nervous system

Fampridine‐PR is a voltage‐gated potassium channel inhibitor potentially improving nerve conduction in demyelinated axons. Based on its established clinical efficacy in patients with demyelination in the central nervous system, we assessed if fampridine‐PR is also effective in patients with inflamma...

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Bibliographic Details
Published in:Journal of the peripheral nervous system 2016-06, Vol.21 (2), p.85-87
Main Authors: Leussink, Verena-Isabell, Stettner, Mark, Warnke, Clemens, Hartung, Hans-Peter
Format: Article
Language:English
Subjects:
4-Aminopyridine - administration & dosage
CIDP
demyelination
Disability Evaluation
Drug Delivery Systems
electrophysiology
Employment discrimination
Female
Humans
immune neuropathy
Male
Middle Aged
Nervous system
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - drug therapy
Potassium Channel Blockers - administration & dosage
Severity of Illness Index
Treatment Outcome
voltage-gated potassium channels
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Summary:Fampridine‐PR is a voltage‐gated potassium channel inhibitor potentially improving nerve conduction in demyelinated axons. Based on its established clinical efficacy in patients with demyelination in the central nervous system, we assessed if fampridine‐PR is also effective in patients with inflammatory demyelination of the peripheral nerve. In this small open‐label study, 10 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) were treated with fampridine‐PR 10 mg BID for 28 days and assessed clinically as well as by nerve conduction studies. In this study, Fampridine‐PR failed to improve CIDP based on clinical measures and nerve conduction studies. Our findings suggest that Fampridine‐PR appears to be ineffective in demyelinating polyneuropathies. These observations may indicate a more complex mode of action beyond improving action potential conduction in demyelinated axons.
ISSN:1085-9489
1529-8027
DOI:10.1111/jns.12169