Changes in the Expression of the Prolactin Receptor (PRLR) Gene in Different Physiological Stages in the Mammary Gland of the Iranian Adani Goat

• Published in: Reproduction in domestic animals 2016-08, Vol.51 (4), p.585-590
• Main Authors: Morammazi, S, Masoudi, AA, Vaez Torshizi, R, Pakdel, A
• Format: Article
• Language: English
• Subjects: Animal reproduction; Animals; Breastfeeding & lactation; Breeding; Cattle; Drying; Environmental changes; Epithelium; Female; Gene expression; Gene Expression Regulation - physiology; Genetic diversity; Genetic factors; Goats; Goats - genetics; Goats - physiology; Hormones; Iran; Lactation; Lactation - physiology; Mammary gland; Mammary Glands, Animal - metabolism; Mathematical models; Physiological effects; Physiology; Prolactin; Real-Time Polymerase Chain Reaction - veterinary; Receptors; Receptors, Prolactin - genetics; Receptors, Prolactin - metabolism; Regression analysis; Regression models; RNA - metabolism; Statistical analysis; Transcription
• ISSN: 0936-6768; 1439-0531
• DOI: 10.1111/rda.12723

Contents The actions of prolactin hormone are mediated by prolactin receptor (PRLR), and proliferation and differentiation of secretory mammary epithelium are dependent on the presence of its receptors. To understand the PRLR expression pattern in mammary gland of dairy goat during different lactation stages, in this study, we first estimated the milk yield breeding value by multitrait random regression model and then compared the expression of the gene in different physiological stage of mammary gland between high‐ and low‐breeding value groups. We assayed the transcription level of the gene by quantitative real‐time PCR method, and its outcomes were analysed by a statistical model containing breeding value groups, sampling times and their interactions as fixed effects. The results indicated that the expression levels of PRLR gene were significantly upregulated in the drying stage (p