Synthesis of tyrosyl-DNA phosphodiesterase I inhibitors

[Display omitted] •Efficient glycosylation.•Synthesis of tyrosyl inhibitors using cheap and readily available starting materials.•Simple and efficient synthesis of compounds 3 and 5 with good overall yield. The first report for the synthesis of tyrosyl-DNA phosphodiesterase I inhibitors 3,4-dimethox...

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Bibliographic Details
Published in:Tetrahedron letters 2016-06, Vol.57 (24), p.2652-2654
Main Authors: Nale, Sagar D., Jadhav, Vrushali H.
Format: Article
Language:English
Subjects:
Glycosylation
Inhibitors
Tyrosyl-DNA
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Summary:[Display omitted] •Efficient glycosylation.•Synthesis of tyrosyl inhibitors using cheap and readily available starting materials.•Simple and efficient synthesis of compounds 3 and 5 with good overall yield. The first report for the synthesis of tyrosyl-DNA phosphodiesterase I inhibitors 3,4-dimethoxyphenol-1-β-d-(6′-O-galloyl)glucopyranoside 3 and 3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol 2-β-d-(6′-O-galloyl) glucopyranoside 5 has been accomplished starting from readily available d-glucose as a starting material. An efficient and general approach has been reported for the synthesis of compounds 3 and 5 with an overall yield of 26% and 27%, respectively.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.05.017