Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin

Abstract Background Intravenous lipid emulsion eliminates the toxicity related symptoms for several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. Methods Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats...

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Published in:The American journal of emergency medicine 2016-06, Vol.34 (6), p.1112-1116
Main Authors: Yurtlu, Bülent Serhan, M.D, Özbilgin, Şule, M.D, Yurtlu, Derya Arslan, M.D, Boztaş, Nilay, M.D, Kamacı, Gonca, D.V.M, Akaltun, Mahmut, Hancı, Volkan, M.D, Yılmaz, Osman, PhD
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - toxicity
Digoxin - toxicity
Dose-Response Relationship, Drug
Drug dosages
Emergency
Emergency medical care
Emulsions
Fat Emulsions, Intravenous - therapeutic use
Heart Arrest - etiology
Heart Arrest - prevention & control
Heart rate
Hypotheses
Infusions, Intravenous
Intensive care
Laboratory animals
Lipids
Medical research
Mortality
Rats
Rats, Wistar
Rodents
Studies
Ventilation
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cited_by cdi_FETCH-LOGICAL-c472t-591f84d6d961a31eed6ea8d413e92a07b69b4476daae334178fda7ba171ccbe43
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container_issue 6
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container_title The American journal of emergency medicine
container_volume 34
creator Yurtlu, Bülent Serhan, M.D
Özbilgin, Şule, M.D
Yurtlu, Derya Arslan, M.D
Boztaş, Nilay, M.D
Kamacı, Gonca, D.V.M
Akaltun, Mahmut
Hancı, Volkan, M.D
Yılmaz, Osman, PhD
description Abstract Background Intravenous lipid emulsion eliminates the toxicity related symptoms for several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. Methods Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 ml/h (0.25 mg/ml). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 ml/kg intravenous lipid emulsion (Group L) or saline (Group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded. Results Mean time until asystole development in Groups C and L were 21.28 ± 8.61 min and 32.00 ± 5.41 min, respectively (p < 0.05). The mean lethal doses of digoxin in the Groups C and L were 3.97 ± 1.54 mg/kg, and 6.09 ± 0.96 mg/kg, respectively (p < 0.05). Conclusion Intravenous lipid emulsion prolonged the time until asystole development and cumulative lethal dose in rats intoxicated with digoxin.
doi_str_mv 10.1016/j.ajem.2016.03.038
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We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. Methods Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 ml/h (0.25 mg/ml). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 ml/kg intravenous lipid emulsion (Group L) or saline (Group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded. Results Mean time until asystole development in Groups C and L were 21.28 ± 8.61 min and 32.00 ± 5.41 min, respectively (p &lt; 0.05). The mean lethal doses of digoxin in the Groups C and L were 3.97 ± 1.54 mg/kg, and 6.09 ± 0.96 mg/kg, respectively (p &lt; 0.05). Conclusion Intravenous lipid emulsion prolonged the time until asystole development and cumulative lethal dose in rats intoxicated with digoxin.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2016.03.038</identifier><identifier>PMID: 27073138</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Anti-Arrhythmia Agents - toxicity ; Digoxin - toxicity ; Dose-Response Relationship, Drug ; Drug dosages ; Emergency ; Emergency medical care ; Emulsions ; Fat Emulsions, Intravenous - therapeutic use ; Heart Arrest - etiology ; Heart Arrest - prevention &amp; control ; Heart rate ; Hypotheses ; Infusions, Intravenous ; Intensive care ; Laboratory animals ; Lipids ; Medical research ; Mortality ; Rats ; Rats, Wistar ; Rodents ; Studies ; Ventilation</subject><ispartof>The American journal of emergency medicine, 2016-06, Vol.34 (6), p.1112-1116</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-591f84d6d961a31eed6ea8d413e92a07b69b4476daae334178fda7ba171ccbe43</citedby><cites>FETCH-LOGICAL-c472t-591f84d6d961a31eed6ea8d413e92a07b69b4476daae334178fda7ba171ccbe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27073138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yurtlu, Bülent Serhan, M.D</creatorcontrib><creatorcontrib>Özbilgin, Şule, M.D</creatorcontrib><creatorcontrib>Yurtlu, Derya Arslan, M.D</creatorcontrib><creatorcontrib>Boztaş, Nilay, M.D</creatorcontrib><creatorcontrib>Kamacı, Gonca, D.V.M</creatorcontrib><creatorcontrib>Akaltun, Mahmut</creatorcontrib><creatorcontrib>Hancı, Volkan, M.D</creatorcontrib><creatorcontrib>Yılmaz, Osman, PhD</creatorcontrib><title>Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Abstract Background Intravenous lipid emulsion eliminates the toxicity related symptoms for several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. Methods Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 ml/h (0.25 mg/ml). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 ml/kg intravenous lipid emulsion (Group L) or saline (Group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded. Results Mean time until asystole development in Groups C and L were 21.28 ± 8.61 min and 32.00 ± 5.41 min, respectively (p &lt; 0.05). The mean lethal doses of digoxin in the Groups C and L were 3.97 ± 1.54 mg/kg, and 6.09 ± 0.96 mg/kg, respectively (p &lt; 0.05). 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We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. Methods Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 ml/h (0.25 mg/ml). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 ml/kg intravenous lipid emulsion (Group L) or saline (Group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded. Results Mean time until asystole development in Groups C and L were 21.28 ± 8.61 min and 32.00 ± 5.41 min, respectively (p &lt; 0.05). The mean lethal doses of digoxin in the Groups C and L were 3.97 ± 1.54 mg/kg, and 6.09 ± 0.96 mg/kg, respectively (p &lt; 0.05). Conclusion Intravenous lipid emulsion prolonged the time until asystole development and cumulative lethal dose in rats intoxicated with digoxin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27073138</pmid><doi>10.1016/j.ajem.2016.03.038</doi><tpages>5</tpages></addata></record>
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ispartof The American journal of emergency medicine, 2016-06, Vol.34 (6), p.1112-1116
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subjects Animals
Anti-Arrhythmia Agents - toxicity
Digoxin - toxicity
Dose-Response Relationship, Drug
Drug dosages
Emergency
Emergency medical care
Emulsions
Fat Emulsions, Intravenous - therapeutic use
Heart Arrest - etiology
Heart Arrest - prevention & control
Heart rate
Hypotheses
Infusions, Intravenous
Intensive care
Laboratory animals
Lipids
Medical research
Mortality
Rats
Rats, Wistar
Rodents
Studies
Ventilation
title Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin
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