Portal hypertension in patients with cirrhosis: indirect assessment of hepatic venous pressure gradient by measuring azygos flow with 2D-cine phase-contrast magnetic resonance imaging

Objectives To measure azygos, portal and aortic flow by two-dimensional cine phase-contrast magnetic resonance imaging (2D-cine PC MRI), and to compare the MRI values to hepatic venous pressure gradient (HVPG) measurements, in patients with cirrhosis. Methods Sixty-nine patients with cirrhosis were...

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Bibliographic Details
Published in:European radiology 2016-07, Vol.26 (7), p.1981-1990
Main Authors: Gouya, Hervé, Grabar, Sophie, Vignaux, Olivier, Saade, Anastasia, Pol, Stanislas, Legmann, Paul, Sogni, Philippe
Format: Article
Language:English
Subjects:
Adult
Aged
Aorta - physiopathology
Area Under Curve
Azygos Vein - physiopathology
Biopsy
Clinical medicine
Diagnostic Radiology
Endoscopy
Female
Hepatic Veins - physiology
Humans
Hypertension
Hypertension, Portal - diagnostic imaging
Hypertension, Portal - physiopathology
Imaging
Internal Medicine
Interventional Radiology
Linear Models
Liver - blood supply
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - physiopathology
Liver diseases
Magnetic Resonance
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine - methods
Male
Medicine
Medicine & Public Health
Microscopy, Phase-Contrast - methods
Middle Aged
Neuroradiology
Portal Pressure - physiology
Prospective Studies
Radiology
Regional Blood Flow - physiology
Regression Analysis
ROC Curve
Ultrasound
Venous Pressure - physiology
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Summary:Objectives To measure azygos, portal and aortic flow by two-dimensional cine phase-contrast magnetic resonance imaging (2D-cine PC MRI), and to compare the MRI values to hepatic venous pressure gradient (HVPG) measurements, in patients with cirrhosis. Methods Sixty-nine patients with cirrhosis were prospectively included. All patients underwent HVPG measurements, upper gastrointestinal endoscopy and 2D-cine PC MRI measurements of azygos, portal and aortic blood flow. Univariate and multivariate regression analyses were used to evaluate the correlation between the blood flow and HVPG. The performance of 2D-cine PC MRI to diagnose severe portal hypertension (HVPG ≥ 16 mmHg) was determined by receiver operating characteristic curve (ROC) analysis, and area under the curves (AUC) were compared. Results Azygos and aortic flow values were associated with HVPG in univariate linear regression model. Azygos flow ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-015-3991-x