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Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study
Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of BDNF a...
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| Published in: | Molecular neurobiology 2016-07, Vol.53 (5), p.2869-2877 |
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| container_end_page | 2877 |
| container_issue | 5 |
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| container_title | Molecular neurobiology |
| container_volume | 53 |
| creator | Sha’ari, Hidayati Mohd Haerian, Batoul Sadat Baum, Larry Tan, Hui Jan Rafia, Mohd Hanip Kwan, Patrick Cherny, Stacey S. Sham, Pak Chung Gui, Hongsheng Raymond, Azman Ali Lim, Kheng Seang Mohamed, Zahurin |
| description | Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of
BDNF
and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (
p
= 0.00003,
p
= 0.0002, and
p
= 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC,
p
= 0.004 and T vs. C,
p
= 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (
p
= 0.005). The T
rs6265
-C
rs7103411
-T
rs7127507
was significantly associated with cryptogenic epilepsy in Malaysian Indians (
p
= 0.00005). In conclusion, our results suggest that
BDNF
polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese. |
| doi_str_mv | 10.1007/s12035-015-9150-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808626204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4084912451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-9ded09ca910e4643e225be59f5267421e73310329f692af8df67983d1f32ac873</originalsourceid><addsrcrecordid>eNqFkc1O3DAUha2KCqaUB2CDLLFhk_ZeO_5jBwO0lWiL-rO2QuIwhiQOdqJq3r5JhyKEhFjdhb9zfO2PkH2EDwigPiZkwEUGKDKDAjJ8QxYohMkQNdsiC9CGZ0rmeoe8S-kWgDEEtU12mNBKCsQFuTpJKZS-GHzoaKjp6dm3C3oVmnUbYr_yqU30jx9WdFg5-sOnu5k5733j-rQ-pgX9OjaDL103uEh_DmO1fk_e1kWT3N7D3CW_L85_LT9nl98_fVmeXGZlDmLITOUqMGVhEFwuc-4YE9dOmFowqXKGTnGOwJmppWFFrataKqN5hTVnRakV3yVHm94-hvvRpcG2PpWuaYrOhTFZ1KAlkwzy11Flpv8wCtiEHj5Db8MYu-kh_yiJ824ThRuqjCGl6GrbR98WcW0R7GzGbszYyYydzdg5c_DQPF63rnpM_FcxAWwDpOmou3HxydUvtv4FnkqV4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1795617421</pqid></control><display><type>article</type><title>Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study</title><source>Springer Nature</source><creator>Sha’ari, Hidayati Mohd ; Haerian, Batoul Sadat ; Baum, Larry ; Tan, Hui Jan ; Rafia, Mohd Hanip ; Kwan, Patrick ; Cherny, Stacey S. ; Sham, Pak Chung ; Gui, Hongsheng ; Raymond, Azman Ali ; Lim, Kheng Seang ; Mohamed, Zahurin</creator><creatorcontrib>Sha’ari, Hidayati Mohd ; Haerian, Batoul Sadat ; Baum, Larry ; Tan, Hui Jan ; Rafia, Mohd Hanip ; Kwan, Patrick ; Cherny, Stacey S. ; Sham, Pak Chung ; Gui, Hongsheng ; Raymond, Azman Ali ; Lim, Kheng Seang ; Mohamed, Zahurin</creatorcontrib><description>Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of
BDNF
and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (
p
= 0.00003,
p
= 0.0002, and
p
= 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC,
p
= 0.004 and T vs. C,
p
= 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (
p
= 0.005). The T
rs6265
-C
rs7103411
-T
rs7127507
was significantly associated with cryptogenic epilepsy in Malaysian Indians (
p
= 0.00005). In conclusion, our results suggest that
BDNF
polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-015-9150-1</identifier><identifier>PMID: 25876511</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Biomedical and Life Sciences ; Biomedicine ; Brain-Derived Neurotrophic Factor - chemistry ; Brain-Derived Neurotrophic Factor - genetics ; Case-Control Studies ; Cell Biology ; Demography ; Epilepsy ; Epilepsy - genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Health risk assessment ; Hong Kong ; Humans ; Malaysia ; Male ; Neurobiology ; Neurology ; Neurosciences ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Risk Factors</subject><ispartof>Molecular neurobiology, 2016-07, Vol.53 (5), p.2869-2877</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9ded09ca910e4643e225be59f5267421e73310329f692af8df67983d1f32ac873</citedby><cites>FETCH-LOGICAL-c405t-9ded09ca910e4643e225be59f5267421e73310329f692af8df67983d1f32ac873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25876511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sha’ari, Hidayati Mohd</creatorcontrib><creatorcontrib>Haerian, Batoul Sadat</creatorcontrib><creatorcontrib>Baum, Larry</creatorcontrib><creatorcontrib>Tan, Hui Jan</creatorcontrib><creatorcontrib>Rafia, Mohd Hanip</creatorcontrib><creatorcontrib>Kwan, Patrick</creatorcontrib><creatorcontrib>Cherny, Stacey S.</creatorcontrib><creatorcontrib>Sham, Pak Chung</creatorcontrib><creatorcontrib>Gui, Hongsheng</creatorcontrib><creatorcontrib>Raymond, Azman Ali</creatorcontrib><creatorcontrib>Lim, Kheng Seang</creatorcontrib><creatorcontrib>Mohamed, Zahurin</creatorcontrib><title>Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of
BDNF
and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (
p
= 0.00003,
p
= 0.0002, and
p
= 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC,
p
= 0.004 and T vs. C,
p
= 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (
p
= 0.005). The T
rs6265
-C
rs7103411
-T
rs7127507
was significantly associated with cryptogenic epilepsy in Malaysian Indians (
p
= 0.00005). In conclusion, our results suggest that
BDNF
polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain-Derived Neurotrophic Factor - chemistry</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Demography</subject><subject>Epilepsy</subject><subject>Epilepsy - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Health risk assessment</subject><subject>Hong Kong</subject><subject>Humans</subject><subject>Malaysia</subject><subject>Male</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc1O3DAUha2KCqaUB2CDLLFhk_ZeO_5jBwO0lWiL-rO2QuIwhiQOdqJq3r5JhyKEhFjdhb9zfO2PkH2EDwigPiZkwEUGKDKDAjJ8QxYohMkQNdsiC9CGZ0rmeoe8S-kWgDEEtU12mNBKCsQFuTpJKZS-GHzoaKjp6dm3C3oVmnUbYr_yqU30jx9WdFg5-sOnu5k5733j-rQ-pgX9OjaDL103uEh_DmO1fk_e1kWT3N7D3CW_L85_LT9nl98_fVmeXGZlDmLITOUqMGVhEFwuc-4YE9dOmFowqXKGTnGOwJmppWFFrataKqN5hTVnRakV3yVHm94-hvvRpcG2PpWuaYrOhTFZ1KAlkwzy11Flpv8wCtiEHj5Db8MYu-kh_yiJ824ThRuqjCGl6GrbR98WcW0R7GzGbszYyYydzdg5c_DQPF63rnpM_FcxAWwDpOmou3HxydUvtv4FnkqV4g</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Sha’ari, Hidayati Mohd</creator><creator>Haerian, Batoul Sadat</creator><creator>Baum, Larry</creator><creator>Tan, Hui Jan</creator><creator>Rafia, Mohd Hanip</creator><creator>Kwan, Patrick</creator><creator>Cherny, Stacey S.</creator><creator>Sham, Pak Chung</creator><creator>Gui, Hongsheng</creator><creator>Raymond, Azman Ali</creator><creator>Lim, Kheng Seang</creator><creator>Mohamed, Zahurin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study</title><author>Sha’ari, Hidayati Mohd ; Haerian, Batoul Sadat ; Baum, Larry ; Tan, Hui Jan ; Rafia, Mohd Hanip ; Kwan, Patrick ; Cherny, Stacey S. ; Sham, Pak Chung ; Gui, Hongsheng ; Raymond, Azman Ali ; Lim, Kheng Seang ; Mohamed, Zahurin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9ded09ca910e4643e225be59f5267421e73310329f692af8df67983d1f32ac873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain-Derived Neurotrophic Factor - 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Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sha’ari, Hidayati Mohd</au><au>Haerian, Batoul Sadat</au><au>Baum, Larry</au><au>Tan, Hui Jan</au><au>Rafia, Mohd Hanip</au><au>Kwan, Patrick</au><au>Cherny, Stacey S.</au><au>Sham, Pak Chung</au><au>Gui, Hongsheng</au><au>Raymond, Azman Ali</au><au>Lim, Kheng Seang</au><au>Mohamed, Zahurin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>53</volume><issue>5</issue><spage>2869</spage><epage>2877</epage><pages>2869-2877</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of
BDNF
and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (
p
= 0.00003,
p
= 0.0002, and
p
= 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC,
p
= 0.004 and T vs. C,
p
= 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (
p
= 0.005). The T
rs6265
-C
rs7103411
-T
rs7127507
was significantly associated with cryptogenic epilepsy in Malaysian Indians (
p
= 0.00005). In conclusion, our results suggest that
BDNF
polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25876511</pmid><doi>10.1007/s12035-015-9150-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-7648 |
| ispartof | Molecular neurobiology, 2016-07, Vol.53 (5), p.2869-2877 |
| issn | 0893-7648 1559-1182 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808626204 |
| source | Springer Nature |
| subjects | Adult Biomedical and Life Sciences Biomedicine Brain-Derived Neurotrophic Factor - chemistry Brain-Derived Neurotrophic Factor - genetics Case-Control Studies Cell Biology Demography Epilepsy Epilepsy - genetics Female Genetic Association Studies Genetic Predisposition to Disease Health risk assessment Hong Kong Humans Malaysia Male Neurobiology Neurology Neurosciences Polymorphism Polymorphism, Single Nucleotide - genetics Risk Factors |
| title | Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study |
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