Trousseau's Syndrome due to Anaplastic Thyroid Carcinoma Presenting with Multiple Ischemic Strokes

• Published in: Internal Medicine 2016/06/15, Vol.55(12), pp.1637-1639
• Main Authors: Hirunagi, Tomoki, Kiriyama, Ayami, Fujino, Masahiko, Goto, Yoji, Mano, Kazuo
• Format: Article
• Language: English
• Subjects: Aged, 80 and over; anaplastic thyroid carcinoma; Cerebral Arteries - diagnostic imaging; Cerebral Arteries - pathology; Cerebral Infarction - diagnostic imaging; Cerebral Infarction - etiology; Cerebral Infarction - therapy; coagulation abnormality; Frontal Lobe - diagnostic imaging; Frontal Lobe - pathology; Humans; ischemic stroke; Japan; Magnetic Resonance Imaging; Male; Syndrome; Thyroid Carcinoma, Anaplastic - complications; Thyroid Carcinoma, Anaplastic - diagnostic imaging; Thyroid Carcinoma, Anaplastic - pathology; Tomography, X-Ray Computed; Trousseau's syndrome
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.55.6063

Trousseau's syndrome is characterized by a cerebral or systemic thromboembolism caused by coagulation abnormalities in malignancy. We herein report a case of multiple ischemic strokes as the initial manifestation of anaplastic thyroid carcinoma (ATC). An 86-year-old man was admitted to our hospital due to a sudden-onset weakness of the left limbs. Brain magnetic resonance imaging revealed multiple ischemic lesions in the right middle cerebral artery territory and a mass in the left frontal lobe. Computed tomography revealed a thyroid mass and multiple lung tumors. A diagnosis of ATC was confirmed by a thyroid biopsy. Our case indicates that ATC should be considered as a cause of Trousseau's syndrome.