Factors associated with radiologic progression of non-cystic fibrosis bronchiectasis during long-term follow-up

• Published in: Respirology (Carlton, Vic.) Vic.), 2016-08, Vol.21 (6), p.1049-1054
• Main Authors: Park, Jisoo, Kim, Sejoong, Lee, Yeon Joo, Park, Jong Sun, Cho, Young-Jae, Yoon, Ho Il, Lee, Kyoung-won, Lee, Choon-Taek, Lee, Jae Ho
• Format: Article
• Language: English
• Subjects: Bhalla score; Body Mass Index; bronchiectasis; Bronchiectasis - diagnosis; Bronchiectasis - diagnostic imaging; Bronchiectasis - epidemiology; Bronchiectasis - physiopathology; Disease Progression; Electronic Health Records; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mycobacterium; Pseudomonas aeruginosa; Pseudomonas aeruginosa - isolation & purification; radiologic progression; Republic of Korea - epidemiology; Respiratory Function Tests; Respiratory System - diagnostic imaging; Respiratory System - physiopathology; Risk Factors; Tomography, X-Ray Computed - methods
• ISSN: 1323-7799; 1440-1843
• DOI: 10.1111/resp.12768

Background and objective Non‐cystic fibrosis (CF) bronchiectasis is a chronic airway inflammatory disease, exhibiting a diverse array of clinical courses. The purpose of this study was to determine the factors that predict radiologic progression of non‐CF bronchiectasis during a long‐term follow‐up. Methods We reviewed the electronic medical records that included pulmonary function test data from non‐CF bronchiectasis patients, who were older than 18 years of age with a follow‐up of computerized tomography for more than 5 years. The original Bhalla score was used to determine the radiologic severity of non‐CF bronchiectasis. Results A total of 155 patients (mean age, 59.6 years; male, 45.2%) were included for the final analysis. The mean follow up time was 7.11 ± 1.42 (5–10) years. The baseline Bhalla score was 9.52 ± 3.14 (4–19), and the change of Bhalla score was 0.55 ± 1.14 (−2 to 5). The Bhalla score was increased in 56 patients (36.1%) but not in 99 patients (63.9%). The Bhalla score change was significantly associated with the age at diagnosis (p = 0.037), body mass index (BMI, p = 0.012), chronic infection of Pseudomonas aeruginosa (p = 0.005) or isolation of nontuberculous mycobacterium (p = 0.042) in respiratory specimens. In a multivariate analysis, BMI and isolation of P. aeruginosa were significantly related with the Bhalla score change. Conclusion The radiologic progression of non‐CF bronchiectasis was associated with lower BMI and isolation of P. aeruginosa in respiratory specimens. The radiologic progression of non‐CF bronchiectasis was associated with lower BMI and isolation of Pseudomonas aeruginosa in respiratory specimens.