The intranasal vaccination of pregnant dams with Intimin and EspB confers protection in neonatal mice from Escherichia coli (EHEC) O157:H7 infection

Highlights • Vaccination of dams with EHEC antigens Intimin and EspB leads to a passive immunization of newborn mice. • The maternal transfer resulted in an increase in serum IgG against γ-Int C280 and EspB. • The maternal transfer reduced the excretion and renal damage after challenge.

Saved in:
Bibliographic Details
Published in:Vaccine 2016-05, Vol.34 (25), p.2793-2797
Main Authors: Rabinovitz, B.C, Larzábal, M, Vilte, D.A, Cataldi, A, Mercado, E.C
Format: Article
Language:English
Subjects:
Adhesins, Bacterial - immunology
Administration, Intranasal
Allergy and Immunology
Amino acids
Animals
Antibiotics
Antibodies, Bacterial - blood
Bacterial Outer Membrane Proteins - immunology
Colonization
Conflicts of interest
Disease
E coli
Escherichia coli
Escherichia coli Infections - prevention & control
Escherichia coli O157
Escherichia coli Proteins - immunology
Escherichia coli Vaccines - administration & dosage
Escherichia coli Vaccines - immunology
Female
Females
Immunity, Maternally-Acquired
Immunization
Immunoglobulin G - blood
Immunoglobulins
Infections
Mice
Mice, Inbred BALB C
Mortality
Neonates
Placenta
Pregnancy
Proteins
Recombinant Proteins - immunology
Urea
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Vaccination of dams with EHEC antigens Intimin and EspB leads to a passive immunization of newborn mice. • The maternal transfer resulted in an increase in serum IgG against γ-Int C280 and EspB. • The maternal transfer reduced the excretion and renal damage after challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.04.056