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The intranasal vaccination of pregnant dams with Intimin and EspB confers protection in neonatal mice from Escherichia coli (EHEC) O157:H7 infection
Highlights • Vaccination of dams with EHEC antigens Intimin and EspB leads to a passive immunization of newborn mice. • The maternal transfer resulted in an increase in serum IgG against γ-Int C280 and EspB. • The maternal transfer reduced the excretion and renal damage after challenge.
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| Published in: | Vaccine 2016-05, Vol.34 (25), p.2793-2797 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c481t-4bfdc3c74ac2bba0ca2a86f5eb357b579ff465f5eb87daf1b7e3a70d85599a2a3 |
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| cites | cdi_FETCH-LOGICAL-c481t-4bfdc3c74ac2bba0ca2a86f5eb357b579ff465f5eb87daf1b7e3a70d85599a2a3 |
| container_end_page | 2797 |
| container_issue | 25 |
| container_start_page | 2793 |
| container_title | Vaccine |
| container_volume | 34 |
| creator | Rabinovitz, B.C Larzábal, M Vilte, D.A Cataldi, A Mercado, E.C |
| description | Highlights • Vaccination of dams with EHEC antigens Intimin and EspB leads to a passive immunization of newborn mice. • The maternal transfer resulted in an increase in serum IgG against γ-Int C280 and EspB. • The maternal transfer reduced the excretion and renal damage after challenge. |
| doi_str_mv | 10.1016/j.vaccine.2016.04.056 |
| format | article |
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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2016-05, Vol.34 (25), p.2793-2797 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adhesins, Bacterial - immunology Administration, Intranasal Allergy and Immunology Amino acids Animals Antibiotics Antibodies, Bacterial - blood Bacterial Outer Membrane Proteins - immunology Colonization Conflicts of interest Disease E coli Escherichia coli Escherichia coli Infections - prevention & control Escherichia coli O157 Escherichia coli Proteins - immunology Escherichia coli Vaccines - administration & dosage Escherichia coli Vaccines - immunology Female Females Immunity, Maternally-Acquired Immunization Immunoglobulin G - blood Immunoglobulins Infections Mice Mice, Inbred BALB C Mortality Neonates Placenta Pregnancy Proteins Recombinant Proteins - immunology Urea Vaccines |
| title | The intranasal vaccination of pregnant dams with Intimin and EspB confers protection in neonatal mice from Escherichia coli (EHEC) O157:H7 infection |
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