Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells

Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understo...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2015-07, Vol.195 (1), p.36-40
Main Authors: Sturge, Carolyn R, Burger, Elise, Raetz, Megan, Hooper, Lora V, Yarovinsky, Felix
Format: Article
Language:English
Subjects:
Animals
Cell Degranulation - immunology
Cell Lineage - immunology
Cytoplasmic Granules - immunology
Gene Expression Regulation, Developmental
Immunity, Innate - genetics
Immunophenotyping
Interferon-gamma - genetics
Interferon-gamma - immunology
Mice
Mice, Knockout
Neutrophil Activation
Neutrophils - cytology
Neutrophils - immunology
Signal Transduction
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Summary:Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-γ production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-γ upon neutrophil activation, the first step during responses to many microbial infections.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1500366