Exercise and Preexercise Nutrition as Treatment for McArdle Disease

ABSTRACTMcArdle disease is due to an inborn defect in the muscle isoform of glycogen phosphorylase (or “myophosphorylase”), the enzyme that catalyzes the first step of glycogenolysis. This condition is still not fully understood, and although advances in research would help patients immeasurably, th...

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Published in:Medicine and science in sports and exercise 2016-04, Vol.48 (4), p.673-679
Main Authors: NOGALES-GADEA, GISELA, SANTALLA, ALFREDO, BALLESTER-LOPEZ, ALFONSINA, ARENAS, JOAQUÍN, MARTÍN, MIGUEL ANGEL, GODFREY, RICHARD, PINÍS, TOMÀS, PINTOS-MORELL, GUILLEM, COLL-CANTÍ, JAUME, LUCIA, ALEJANDRO
Format: Article
Language:English
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Exercise Therapy
Glycogen Storage Disease Type V - therapy
Humans
Nutritional Physiological Phenomena
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cited_by cdi_FETCH-LOGICAL-c4352-193081d9d86e1a4d97ee102ed1448743b4c146c2ad313b5ab776a8dedcb271793
cites cdi_FETCH-LOGICAL-c4352-193081d9d86e1a4d97ee102ed1448743b4c146c2ad313b5ab776a8dedcb271793
container_end_page 679
container_issue 4
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container_title Medicine and science in sports and exercise
container_volume 48
creator NOGALES-GADEA, GISELA
SANTALLA, ALFREDO
BALLESTER-LOPEZ, ALFONSINA
ARENAS, JOAQUÍN
MARTÍN, MIGUEL ANGEL
GODFREY, RICHARD
PINÍS, TOMÀS
PINTOS-MORELL, GUILLEM
COLL-CANTÍ, JAUME
LUCIA, ALEJANDRO
description ABSTRACTMcArdle disease is due to an inborn defect in the muscle isoform of glycogen phosphorylase (or “myophosphorylase”), the enzyme that catalyzes the first step of glycogenolysis. This condition is still not fully understood, and although advances in research would help patients immeasurably, these would also enhance our understanding of exercise metabolism. It has been 10 yr since the first published report demonstrating the benefits of regular aerobic exercise for these patients. However, misconceptions remain and the value of exercise prescription for patients with McArdle disease is still overlooked. Here, we review the role of exercise in McArdle disease with the aim to better inform health-care professionals and thus better serve the interests of patients. Recommendations for regular exercise together with preexercise nutrition in children and adult patients are also provided along with examples of exercise practice and its benefits.
doi_str_mv 10.1249/MSS.0000000000000812
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subjects Exercise Therapy
Glycogen Storage Disease Type V - therapy
Humans
Nutritional Physiological Phenomena
title Exercise and Preexercise Nutrition as Treatment for McArdle Disease
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