Genetic predisposition for high stress reactivity amplifies effects of early-life adversity

Highlights • ELS exerts short-term effects on bodyweight and behavior in HR, IR, and LR pups. • HR ELS pups show elevated corticosterone levels in the stress hyporesponsive period. • ELS increases the already high HPA axis reactivity of adult HR mice even further. • Lasting effects of ELS include hy...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-08, Vol.70, p.85-97
Main Authors: McIlwrick, Silja, Rechenberg, Alexandra, Matthes, Mariana, Burgstaller, Jessica, Schwarzbauer, Thomas, Chen, Alon, Touma, Chadi
Format: Article
Language:English
Subjects:
Adaptation, Psychological
Animals
Brain - metabolism
Corticosterone - metabolism
Crh
Depressive Disorder, Major - genetics
Depressive Disorder, Major - metabolism
Disease Models, Animal
Early-life stress
Emotions
Endocrinology & Metabolism
Endophenotypes - metabolism
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
HPA axis
Hypothalamo-Hypophyseal System - metabolism
Major depressive disorder
Male
Mice
Mood Disorders - genetics
Mood Disorders - metabolism
Neurosecretory Systems - metabolism
Pituitary-Adrenal System - metabolism
Pregnancy
Psychiatry
Random Allocation
Stress reactivity mouse model
Stress, Psychological - genetics
Stress, Psychological - metabolism
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Summary:Highlights • ELS exerts short-term effects on bodyweight and behavior in HR, IR, and LR pups. • HR ELS pups show elevated corticosterone levels in the stress hyporesponsive period. • ELS increases the already high HPA axis reactivity of adult HR mice even further. • Lasting effects of ELS include hyperactive stress-coping behavior in HR mice. • ELS affects the expression of CRH mRNA in the PVN and hippocampus of HR mice
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.04.023