PO-0051Zinc And Copper Disorders In Children With Diabetes Type 1

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A266-A267
• Main Authors: Smahi, M, Aribi, M, Hamouda, L, Labadi, L, Ysmaildahlok, L, Bendeddeouche, S
• Format: Article
• Language: English
• ISSN: 0003-9888
• DOI: 10.1136/archdischild-2014-307384.724

Background and aimsType 1 diabetes (T1D) is an autoimmune disease that results from the progressive and selective destruction of pancreatic beta cells. Trace elements have a key role as well as in adaptive immunity in inflammatory processes. The aim of this study was to measure circulating levels of Zinc (Zn), Copper (Cu), and protein fractions in patients with T1D.MethodsSixty (60) subjects aged less than 15 years, divided into two similar groups (30 with recently type 1 diabetes and 30 controls) were recruited in the Department of Paediatrics of Tlemcen University Hospital. Zinc and copper were measured by polarimetry. The protein fractions were measured by zone electrophoresis on cellulose acetate (PFIC, serum protein electrophoresis) (HELENA, USA).ResultsSerum Zn and Cu levels were significantly elevated in type 1 diabetes compared with controls (respectively, p = 0.001, p = 0.002). 0,05)." >However, the percentage of alpha -1, alpha -2, beta and gamma globulins, and the total rate of serum globulins were identical in the two groups (p > 0.05). Conversely, the percentage of albumin and albumin/globulin ratio were significantly decreased in type 1 diabetes compared with controls (p < 0.01 and p < 0.05, respectively).ConclusionDisorders Zn and Cu could be significant immunological abnormalities and inflammatory signs at the beginning of the installation of T1D.