Amyloid β accumulation and inner retinal degenerative changes in Alzheimer’s disease transgenic mouse

•Increased Amyloid β accumulation was observed in retina.•A loss of scotopic threshold response amplitudes was demonstrated in AD mice.•Slight elevation of intraocular pressure was detected.•Retinal thinning particularly related to inner retina was identified. The APP-PS1ΔE9 mouse model of Alzheimer...

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Bibliographic Details
Published in:Neuroscience letters 2016-06, Vol.623, p.52-56
Main Authors: Gupta, Vivek K., Chitranshi, Nitin, Gupta, Veer B., Golzan, Mojtaba, Dheer, Yogita, Wall, Roshana Vander, Georgevsky, Dana, King, Anna E., Vickers, James C., Chung, Roger, Graham, Stuart
Format: Article
Language:English
Subjects:
Aggregation
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Amyloid - metabolism
Amyloid beta
Amyloid beta-Protein Precursor - genetics
Animals
Dark Adaptation
Electrophysiology recordings
Intraocular Pressure
Mice, Transgenic
Optic Nerve - ultrastructure
Presenilin-1 - genetics
Retina
Retina - metabolism
Retina - pathology
Retina - physiopathology
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Summary:•Increased Amyloid β accumulation was observed in retina.•A loss of scotopic threshold response amplitudes was demonstrated in AD mice.•Slight elevation of intraocular pressure was detected.•Retinal thinning particularly related to inner retina was identified. The APP-PS1ΔE9 mouse model of Alzheimer’s disease (AD) exhibits age dependent amyloid β (Aβ) plaque formation in their central nervous system due to high expression of mutated human APP and PSEN1 transgenes. Here we evaluated Aβ deposition and changes in soluble Aβ accumulation in the retinas of aged APP-PS1 mice using a combination of immunofluorescence, retinal flat mounts and western blotting techniques. Aβ accumulation in the retina has previously been shown to be associated with retinal ganglion cell apoptosis in animal models of glaucoma. This study investigated changes in the inner retinal function and structure in APP-PS1 mice using electrophysiology and histological approaches respectively. We report for the first time a significant decline in scotopic threshold response (STR) amplitudes which represents inner retinal function in transgenic animals compared to the wild type counterparts (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2016.04.059