The Impact of Echocardiographic Epicardial Fat Thickness on Outcomes of Cryoballoon-Based Atrial Fibrillation Ablation

Background Evidence from previous studies indicates increased epicardial fat volume, measured using computerized tomography, is significantly associated with recurrence of atrial fibrillation (AF) after catheter ablation. This association is most frequently linked to pro‐inflammatory cytokine releas...

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Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2016-06, Vol.33 (6), p.821-829
Main Authors: Canpolat, Uğur, Aytemir, Kudret, Yorgun, Hikmet, Asil, Serkan, Dural, Muhammed, Özer, Necla
Format: Article
Language:English
Subjects:
Ablation Techniques - statistics & numerical data
Adipose Tissue - diagnostic imaging
Adipose Tissue - pathology
atrial fibrillation
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - epidemiology
Atrial Fibrillation - surgery
Cryotherapy - statistics & numerical data
Echocardiography - statistics & numerical data
epicardial fat
Female
Humans
inflammation
Male
Middle Aged
Organ Size
Pericardium - diagnostic imaging
Pericardium - pathology
Prevalence
Prognosis
recurrence
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Treatment Outcome
Turkey - epidemiology
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Summary:Background Evidence from previous studies indicates increased epicardial fat volume, measured using computerized tomography, is significantly associated with recurrence of atrial fibrillation (AF) after catheter ablation. This association is most frequently linked to pro‐inflammatory cytokine release from epicardial fat tissue. However, there is little data regarding the role of echocardiographically measured epicardial fat thickness (EFT) on catheter ablation outcomes. We aimed to investigate the predictive value of echocardiographically measured EFT on AF recurrence after cryoballoon‐based catheter ablation. Methods A total of 234 patients (51.3% male; mean age, 54.0 ± 10.9 years; 81.2% paroxysmal AF) with symptomatic AF underwent an initial cryoablation procedure. EFT was measured from the parasternal long‐axis view at end‐systole. A 3‐month postablation blanking period was observed. Results At a median follow‐up of 20 (IQR: 13−24) months, 45 patients (19.2%) had developed AF recurrence. EFT thickness was significantly higher among patients with AF recurrence (7.79 ± 2.0 vs. 5.79 ± 1.38, P 
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.13193