Early impact of rotavirus vaccination in a large paediatric hospital in the UK

Summary The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0–15 years tested positive for rotavir...

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Bibliographic Details
Published in:The Journal of hospital infection 2016-06, Vol.93 (2), p.117-120
Main Authors: Hungerford, D, Read, J.M, Cooke, R.P.D, Vivancos, R, Iturriza-Gómara, M, Allen, D.J, French, N, Cunliffe, N
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Community-Acquired Infections - epidemiology
Community-Acquired Infections - prevention & control
Cross Infection - epidemiology
Cross Infection - prevention & control
Epidemiology
Female
Gastroenteritis - epidemiology
Gastroenteritis - prevention & control
Healthcare-associated infection
Hospitals
Humans
Infant
Infant, Newborn
Infectious Disease
Male
Prevalence
Rotavirus
Rotavirus Infections - epidemiology
Rotavirus Infections - immunology
Rotavirus Infections - prevention & control
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - immunology
United Kingdom - epidemiology
Vaccination
Vaccination - utilization
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Summary:Summary The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0–15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72–90%) and 83% (95% CI: 66–92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2015.12.010