Local field potential oscillations of the globus pallidus in cervical and tardive dystonia

Abstract Background Reports about neural oscillatory activity in the globus pallidus internus (GPi) have targeted general (GD) and cervical dystonia (CD), however to our knowledge they are nonexistent for tardive dystonia (TD). Methods Local field potentials (LFPs) from seven CD and five TD patients...

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Bibliographic Details
Published in:Journal of the neurological sciences 2016-07, Vol.366, p.68-73
Main Authors: Trenado, Carlos, Hartmann, Christian, Elben, Saskia, Pauls, K. Amande M, Friggemann, Lena, Groiss, Stefan Jun, Timmermann, Lars, Vesper, Jan, Schnitzler, Alfons, Wojtecki, Lars
Format: Article
Language:English
Subjects:
Adult
Aged
Brain Waves
Cervical and tardive dystonia
Deep Brain Stimulation
Female
Globus pallidus
Globus Pallidus - physiopathology
Humans
Implantable Neurostimulators
Intraoperative Neurophysiological Monitoring
Intraoperative recordings
Local field potentials
Male
Middle Aged
Neurology
Oscillations
Tardive Dyskinesia - physiopathology
Tardive Dyskinesia - surgery
Torticollis - physiopathology
Torticollis - surgery
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Summary:Abstract Background Reports about neural oscillatory activity in the globus pallidus internus (GPi) have targeted general (GD) and cervical dystonia (CD), however to our knowledge they are nonexistent for tardive dystonia (TD). Methods Local field potentials (LFPs) from seven CD and five TD patients were recorded intraoperatively. We compared LFP power in thetadelta, alpha and beta band during rest and sensory palmar stimulation (SPS) in patients with general anesthesia and local/analgo sedation. Results We found prominent LFP power activity in thetadelta for both CD and TD. Unlike TD, a significant difference between rest and SPS was revealed for CD. Conclusions Our data support the presence of LFP oscillatory activity in CD and TD. Thetadelta power modulation in the GPi is suggested as a signature for sensory processing in CD.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2016.04.033