Identification of MBF2 family genes in Bombyx mori and their expression in different tissues and stages and in response to Bacillus bombysepticus infection and starvation

The Multiprotein bridge factor 2 （MBF2） gene was first identified as a coactivator involved in BmFTZ-F 1-mediated activation of the Fushi tarazu gene. Herein, nine homologous genes of MBF2 gene are identified. Evolutionary analysis showed that this gene family is insect-specific and that the family...

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Bibliographic Details
Published in:Insect science 2016-08, Vol.23 (4), p.502-512
Main Authors: Zhou, Chun-Yan, Zha, Xing-Fu, Liu, Chun, Han, Min-Jin, Zhang, Li-Ying, Shi, Pan-Pan, Wang, He, Zheng, Ren-Wen, Xia, Qing-You
Format: Article
Language:English
Subjects:
Animals
Bacillus
Bacillus - physiology
Bombyx - genetics
Bombyx - microbiology
Bombyx - physiology
Bombyx mori
Food Deprivation
Fushi Tarazu Transcription Factors - genetics
Fushi Tarazu Transcription Factors - metabolism
Gene Expression Regulation, Developmental
Genes
Genome, Insect
immunity
Insect Proteins - genetics
Insect Proteins - metabolism
Larva - genetics
Larva - microbiology
Larva - physiology
nutrient metabolism
Pathogens
Phylogeny
physiology
whole-genome scanning
基因家族
基因鉴定
家蚕
感染
组织分布
组织特异性
芽孢杆菌
饥饿
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Summary:The Multiprotein bridge factor 2 （MBF2） gene was first identified as a coactivator involved in BmFTZ-F 1-mediated activation of the Fushi tarazu gene. Herein, nine homologous genes of MBF2 gene are identified. Evolutionary analysis showed that this gene family is insect-specific and that the family members are closely related to response to pathogens （REPAT） genes. Tissue distribution analysis revealed that these genes could be expressed in a tissue-specific manner. Developmental profiles analysis showed that the MBF2 gene family members were highly expressed in the different stages. Analysis of the expression patterns of nine MBF2 family genes showed that Bacillus bombysepticus treatment induced the up-regulation of several MBF2 family genes, including MBF2-4, -7, -9, -8. Furthermore, we found the MBF2 family genes were modulated by starvation and the expression of these genes recovered upon re-feeding, except for MBF2-5, -9. These findings suggested roles for these proteins in insect defense against pathogens and nutrient metabolism, which has an important guiding significance for designing pest control strategies.
ISSN:1672-9609
1744-7917
DOI:10.1111/1744-7917.12349