Luteolin inhibits viral-induced inflammatory response in RAW264.7 cells via suppression of STAT1/3 dependent NF-κB and activation of HO-1

• Published in: Free radical biology & medicine 2016-06, Vol.95, p.180-189
• Main Authors: Liu, Cheng-Wei, Lin, Hui-Wen, Yang, Deng-Jye, Chen, Shih-Yin, Tseng, Jung-Kai, Chang, Tien-Jye, Chang, Yuan-Yen
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - administration & dosage; Drugs, Chinese Herbal - administration & dosage; Gene Expression Regulation - drug effects; Heme Oxygenase-1 - genetics; Herpesvirus 1, Suid - pathogenicity; HO-1; Inflammation - drug therapy; Inflammation - genetics; Inflammation - virology; Luteolin; Luteolin - administration & dosage; Membrane Proteins - genetics; Mice; NF-E2-Related Factor 2 - genetics; NF-kappa B - genetics; NF-κB; Nrf2; Phosphorylation - drug effects; Pseudorabies virus; Pseudorabies virus (PRV); RAW 264.7 Cells; STAT1 Transcription Factor - genetics; STAT1/3; STAT3 Transcription Factor - genetics
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2016.03.019

Luteolin is a common dietary flavonoid present in Chinese herbal medicines that has been reported to have important anti-inflammatory properties. Previous studies have shown that luteolin is an anti-inflammatory and anti-oxidative agent. In this study, the anti-virus inflammatory capacity of luteolin and its molecular mechanisms of action were analyzed. The cytotoxic effects of luteolin were assessed in the presence or absence of pseudorabies virus (PRV) via LDH and MTT assays. The results showed that luteolin (