Increased concentration of plasma TNFR1 and TNFR2 in paediatric lupus nephritis

Background Juvenile-onset systemic lupus erythematous (JSLE) is a debilitating condition that frequently involves the kidneys (lupus nephritis; LN). Tumour necrosis factor alpha (TNF-α), an important pro-inflammatory cytokine, is expressed locally in the kidney and correlates with LN disease activit...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 2016-08, Vol.25 (9), p.1040-1044
Main Authors: Patel, M, Oni, L, Midgley, A, Smith, E, Tullus, K, Marks, S D, Jones, C A, Pilkington, C, Beresford, M W
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Albumin
Anti-DNA antibodies
Antibodies
Child
Children
Creatinine
Creatinine - urine
Enzyme-Linked Immunosorbent Assay
Female
Humans
Inflammation
Kidneys
Lupus
Lupus nephritis
Lupus Nephritis - blood
Lupus Nephritis - urine
Male
Nephritis
Receptors, Tumor Necrosis Factor, Type I - blood
Receptors, Tumor Necrosis Factor, Type II - blood
Serum Albumin - metabolism
Systemic lupus erythematosus
Tumor necrosis factor
Tumor necrosis factor receptors
Tumor necrosis factor-TNF
Tumors
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Juvenile-onset systemic lupus erythematous (JSLE) is a debilitating condition that frequently involves the kidneys (lupus nephritis; LN). Tumour necrosis factor alpha (TNF-α), an important pro-inflammatory cytokine, is expressed locally in the kidney and correlates with LN disease activity. The aim of this study was to ascertain whether soluble receptors for TNF-α (sTNFR1/sTNFR2) are significantly increased in children with LN. Methods Plasma samples were collected from JSLE patients at routine review. Concentrations of sTNFR1 and sTNFR2 were measured (median; interquartile range, IQR) using enzyme-linked immunosorbent assay (ELISA) in 25 JSLE patients (seven LN) and 20 healthy controls (HCs). Results sTNFR2 concentration was significantly increased in JSLE (5149 pg/dl, 3413–8561) compared to HCs (3858 pg/dl, 2254–5165; p = 0.049). sTNFR1 concentration was significantly increased in active LN (n = 7, 1765 pg/dl, IQR 1133–4167) compared to inactive LN (n = 18, 1104 pg/dl, 886–1272; p = 0.018). There was a non-significant increase in sTNFR2 concentration in active LN (9829 pg/dl, 3298–21271) compared to inactive LN (4595 pg/dl, 3345–6993; p = 0.146). sTNFR1 concentration correlated moderately with sTNFR2 (r = 0.66, p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203316631634