Heterogenous haemodynamic effects of adaptive servoventilation therapy in sleeping patients with heart failure and Cheyne–Stokes respiration compared to healthy volunteers

This study investigated the haemodynamic effects of adaptive servoventilation (ASV) in heart failure (HF) patients with Cheyne–Stokes respiration (CSR) versus healthy controls. Twenty-seven HF patients with CSR and 15 volunteers were ventilated for 1 h using a new ASV device (PaceWave™). Haemodynami...

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Bibliographic Details
Published in:Heart and vessels 2016-07, Vol.31 (7), p.1117-1130
Main Authors: Spießhöfer, Jens, Fox, Henrik, Lehmann, Roman, Efken, Christina, Heinrich, Jessica, Bitter, Thomas, Körber, Britta, Horstkotte, Dieter, Oldenburg, Olaf
Format: Article
Language:English
Subjects:
Adult
Aged
Biomedical Engineering and Bioengineering
Blood Pressure
Cardiac Surgery
Cardiology
Case-Control Studies
Cheyne-Stokes Respiration - diagnosis
Cheyne-Stokes Respiration - physiopathology
Cheyne-Stokes Respiration - therapy
Electric Impedance
Equipment Design
Female
Healthy Volunteers
Heart failure
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart Failure - therapy
Hemodynamics
Humans
Lung - physiopathology
Male
Medicine
Medicine & Public Health
Middle Aged
Mitral Valve Insufficiency - complications
Mitral Valve Insufficiency - physiopathology
Original Article
Parasympathetic Nervous System - physiopathology
Prospective Studies
Respiration
Respiration, Artificial - adverse effects
Respiration, Artificial - instrumentation
Respiration, Artificial - methods
Respiratory Mechanics
Sleep
Sleep apnea
Thermodilution
Time Factors
Treatment Outcome
Vascular Surgery
Ventilators, Mechanical
Ventricular Function, Left
Ventricular Function, Right
Ventricular Pressure
Young Adult
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Summary:This study investigated the haemodynamic effects of adaptive servoventilation (ASV) in heart failure (HF) patients with Cheyne–Stokes respiration (CSR) versus healthy controls. Twenty-seven HF patients with CSR and 15 volunteers were ventilated for 1 h using a new ASV device (PaceWave™). Haemodynamics were continuously and non-invasively recorded at baseline, during ASV and after ventilation. Prior to the actual study, a small validation study was performed to validate non-invasive measurement of Stroke volume index (SVI). Non-invasive measurement of SVI showed a marginal overall difference of −0.03 ± 0.41 L/min/m 2 compared to the current gold standard (Thermodilution-based measurement). Stroke volume index (SVI) increased during ASV in HF patients (29.7 ± 5 to 30.4 ± 6 to 28.7 ± 5 mL/m 2 , p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-015-0717-6