PS-277Fully Automated Control Of Inspired Oxygen Based On Oxygen Saturation In Preterm Lambs

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A212-A212
• Main Authors: Huetten, M, Goos, T G, Ophelders, D, Nikiforou, M, Kuypers, E, Willems, M, Dankelman, J, Reiss, IKM, Kramer, B W
• Format: Article
• Language: English
• ISSN: 0003-9888
• DOI: 10.1136/archdischild-2014-307384.577

BackgroundOxygen under- and overexposure has detrimental effects on preterm infants. Controlling the oxygen saturation manually within strict targets is a notoriously difficult and time consuming task which can be facilitated by automated control.AimsTo evaluate the performance of a closed loop fraction of inspired oxygen (FiO2) controller based on oxygen saturation (SpO2) targets when compared to dedicated manual control.MethodsPrematurely delivered lambs (128-132 days of gestation, term 150 d) were intubated and ventilated with volume guaranteed ventilation (Fabian HFO, Acutronic registered ) adjusted to arterial pCO2. SpO2 was measured via pulse oximetry (Radical 7, Masimo registered ). After a stabilisation period of 30 min, lambs were randomised to three hours of ventilation with automated or manual FiO2 control (caretaker-lamb ratio 1:1). Saturation targets were 90-95% according to European guidelines. Data is represented as median [IQR].ResultsTwenty-two lambs were included, 11 in each group. Time spend within the target range was significantly better when the automated controller was used (93.2% [80.6-98.9%] vs. 84.0% [63.8-89.4%], p2 adjustments per hour was higher when the automated controller was used (13.0 [3.0-16.4] vs. 5.7 [2.3-9.8], n.s.).ConclusionsAutomated FiO2 control was effective in this model. These results are especially promising as we compared our device to animals receiving 1:1 care in the manual control group. In a clinical setting, the combination of automated control and dedicated caretakers might even be more effective.