1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus

Highlights • INA-iV3526 provided complete protection against aerosol challenge. • Immunization with INA-iV3526 triggered a strong antibody response. • IM route of immunization provided maximum amount of protection.

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Bibliographic Details
Published in:Vaccine 2016-05, Vol.34 (25), p.2762-2765
Main Authors: Gupta, Paridhi, Sharma, Anuj, Spurgers, Kevin B, Bakken, Russell R, Eccleston, Lori T, Cohen, Jeffrey W, Honnold, Shelley P, Glass, Pamela J, Maheshwari, Radha K
Format: Article
Language:English
Subjects:
Aerosol challenge
Aerosols
Allergy and Immunology
Alphavirus
Animals
Antibodies, Viral - blood
Azides - chemistry
Colleges & universities
Conflicts of interest
Encephalitis
Encephalitis Virus, Venezuelan Equine
Encephalomyelitis, Venezuelan Equine - prevention & control
Health sciences
Immunization
Immunoglobulin G - blood
Inactivated
Iodonaphthyl azide
Laboratory animals
Mice
Neutralization Tests
Prophylaxis
Protection
Reoviridae
Standard deviation
Survival analysis
Terrorism
Togaviridae
Vaccination - methods
Vaccine
Vaccines
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Venezuelan equine encephalitis
Venezuelan equine encephalitis virus
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
Viruses
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Description
Summary:Highlights • INA-iV3526 provided complete protection against aerosol challenge. • Immunization with INA-iV3526 triggered a strong antibody response. • IM route of immunization provided maximum amount of protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.04.049