Protection of rhesus macaques against inhalational anthrax with a Bacillus anthracis capsule conjugate vaccine

Abstract The efficacy of currently licensed anthrax vaccines is largely attributable to a single Bacillus anthracis immunogen, protective antigen. To broaden protection against possible strains resistant to protective antigen-based vaccines, we previously developed a vaccine in which the anthrax pol...

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Bibliographic Details
Published in:Vaccine 2016-07, Vol.34 (34), p.4012-4016
Main Authors: Chabot, Donald J, Ribot, Wilson J, Joyce, Joseph, Cook, James, Hepler, Robert, Nahas, Debbie, Chua, Jennifer, Friedlander, Arthur M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Anthrax
Anthrax - prevention & control
Anthrax Vaccines - immunology
Antibodies, Bacterial - blood
Antigens
Antigens, Bacterial - immunology
Armed forces
Bacillus anthracis
Bacterial Capsules - immunology
Bacterial Toxins - immunology
Capsule
Conjugate
Experiments
Female
Funding
Immunoglobulin G - blood
Immunoglobulin M - blood
Laboratory animals
Macaca mulatta
Male
Medical research
Mortality
Neisseria meningitidis
Peptides
Polyglutamate
Polyglutamic Acid - immunology
Proteins
Rabbits
Respiratory Tract Infections - prevention & control
Rhesus macaque
Studies
Vaccine
Vaccines
Vaccines, Conjugate - immunology
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Summary:Abstract The efficacy of currently licensed anthrax vaccines is largely attributable to a single Bacillus anthracis immunogen, protective antigen. To broaden protection against possible strains resistant to protective antigen-based vaccines, we previously developed a vaccine in which the anthrax polyglutamic acid capsule was covalently conjugated to the outer membrane protein complex of Neisseria meningitidis serotype B and demonstrated that two doses of 2.5 μg of this vaccine conferred partial protection of rhesus macaques against inhalational anthrax . Here, we demonstrate complete protection of rhesus macaques against inhalational anthrax with a higher 50 μg dose of the same capsule conjugate vaccine. These results indicate that B. anthracis capsule is a highly effective vaccine component that should be considered for incorporation in future generation anthrax vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.06.031