Placental cadmium as an additional noninvasive bioindicator of active maternal tobacco smoking

Tobacco smoke (TS) is a mixture of chemicals that is known to exert carcinogenic and endocrine-disrupting effects, as well as adverse effects on various systems. In TS nicotine is the major alkaloid and cadmium (Cd) the most abundant metal ion. The aim of this investigation was to assess exposure to...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2016-01, Vol.79 (11), p.443-446
Main Authors: Piasek, Martina, Jurasović, Jasna, Sekovanić, Ankica, Brajenović, Nataša, Brčić Karačonji, Irena, Mikolić, Anja, Grgec, Antonija Sulimanec, Stasenko, Sandra
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Blood
Cadmium
Cadmium - analysis
Cadmium - metabolism
Cohort Studies
Environmental Pollutants - analysis
Environmental Pollutants - metabolism
Female
Fetal Blood - chemistry
Hair
Hair - chemistry
Humans
Nicotine
Placenta
Placenta - chemistry
Postpartum Period
Pregnancy
Rope
Smoking
Smoking - blood
Smoking - metabolism
Tobacco
Tobacco smoke
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tobacco smoke (TS) is a mixture of chemicals that is known to exert carcinogenic and endocrine-disrupting effects, as well as adverse effects on various systems. In TS nicotine is the major alkaloid and cadmium (Cd) the most abundant metal ion. The aim of this investigation was to assess exposure to Cd attributed to TS in healthy postpartum subjects (mean age 28 years) after term vaginal delivery in a clinical hospital by determining metal levels in maternal blood, placenta, and cord blood in relation to nicotine in maternal hair (12-cm-long samples). Two study groups were compared based upon self-reporting data: smokers (n = 32; continual cigarette smoking 3 months before and 9 months during pregnancy) and nonsmokers (n = 54; including passive smokers whose parameters did not differ from unexposed nonsmokers). In smokers compared to nonsmokers maternal hair nicotine concentrations increased approximately sevenfold, while Cd levels rose fourfold in maternal blood and up to twofold in placenta. Significant positive correlations were noted between maternal hair nicotine and placental Cd, maternal hair nicotine and maternal blood Cd, and placental Cd and maternal blood Cd. Levels of cord blood Cd were low in both study groups (
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2016.1165640