Kawasaki disease and cardiovascular risk: a comprehensive review of subclinical vascular changes in the longer term

Studies of subclinical vascular changes post‐Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima–media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened car...

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Bibliographic Details
Published in:Acta Paediatrica 2016-07, Vol.105 (7), p.752-761
Main Authors: Chen, Katherine Y. H., Curtis, Nigel, Dahdah, Nagib, Kowalski, Remi, Cheung, Michael, Burgner, David P.
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Cardiovascular Diseases - etiology
Carotid Intima-Media Thickness
Coronary artery
Endothelial function
Endothelium, Vascular - physiopathology
Health risk assessment
Health risks
Humans
Kawasaki disease
Mucocutaneous lymph node syndrome
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - physiopathology
Risk Factors
Risk groups
Vascular stiffness
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Summary:Studies of subclinical vascular changes post‐Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima–media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low‐risk groups. Conclusion Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.13367