Effect of Hepatitis C Virus Coinfection on the Content of CD4 super(+) and CD8 super(+) T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4 super(+) T cells and an increase in the count of central CD8 super(+) me...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.281-283
Main Authors: Korolevskaya, L B, Shmagel, K V, Saidakova, E V, Shmagel, NG, Slobodchikova, S V, Chereshnev, V A
Format: Article
Language:English
Subjects:
Hepatitis C virus
Human immunodeficiency virus
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Summary:We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4 super(+) T cells and an increase in the count of central CD8 super(+) memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4 super(+) memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3395-1