Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder

• Published in: Journal of psychiatric research 2016-07, Vol.78, p.65-71
• Main Authors: He, Shen, Liu, Xiaohua, Jiang, Kaida, Peng, Daihui, Hong, Wu, Fang, Yiru, Qian, Yiping, Yu, Shunying, Li, Huafang
• Format: Article
• Language: English
• Subjects: Adult; Antidepressive Agents - therapeutic use; Area Under Curve; Biomarkers - blood; Depressive Disorder, Major - blood; Depressive Disorder, Major - drug therapy; Expression; Female; Follow-Up Studies; Humans; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Major depressive disorder; Male; MicroRNA; MicroRNAs - metabolism; miR-124; PBMC; Psychiatry; Real-Time Polymerase Chain Reaction; ROC Curve; Treatment; Treatment Outcome
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/j.jpsychires.2016.03.015

Abstract Recently, increasing evidence has indicated that dysfunction of microRNA-124 (miR-124) might be involved in the pathophysiology and treatment of major depressive disorder (MDD) in some animal models of depression. However, the role of miR-124 in MDD patients remains unclear. The objective of this study was to investigate whether the miR-124 expression levels in peripheral blood mononuclear cells (PBMCs) were associated with MDD and to evaluate the effects of antidepressant treatment on miR-124 levels. Quantitative real-time PCR was applied to detect miR-124 expression in 32 pre- and post-treatment MDD patients and 30 healthy controls. Our results showed that expression levels of miR-124 from PBMCs in MDD patients were significantly higher than those in healthy controls (p